DNA methylation
[/ˌdiː.ɛnˈeɪ ˌmeθ.əˈleɪ.ʃən/]
nounfemininepl: DNA methylations / methylations
metilação do DNA
1. A biochemical process in which methyl groups (CH₃) are added to cytosine bases in DNA, typically at CpG dinucleotides, affecting gene expression without altering the DNA sequence itself
DNA methylation is a key epigenetic mechanism that regulates gene expression during development.
A metilação do DNA é um mecanismo epigenético fundamental que regula a expressão gênica durante o desenvolvimento.
2. An epigenetic modification that can silence genes or alter chromatin structure, playing a crucial role in cellular differentiation, X-inactivation, and disease pathogenesis
Abnormal DNA methylation patterns have been associated with various cancers and developmental disorders.
Padrões anormais de metilação do DNA foram associados a vários cânceres e distúrbios do desenvolvimento.
3. The covalent addition of a methyl group to the 5-carbon position of cytosine in DNA, catalyzed by DNA methyltransferases
DNA methylation occurs primarily in mammalian genomes at CpG sites.
A metilação do DNA ocorre principalmente em genomas de mamíferos em sítios CpG.
DNA methylation is a fundamental concept in modern molecular biology and genetics research. The terminology is consistent across English and Portuguese scientific communities, with the main difference being ADN vs. DNA in Portugal. This term is essential in contemporary discussions of cancer biology, developmental genetics, and personalized medicine in both Brazilian and international scientific contexts.
Look up more words on Fala2Me
The free English-Portuguese dictionary with real Brazilian accents, NYC slang, conjugator and more
Open Fala2Me →